New Paper Shows B2GPI Changes Structures

We are happy to share our newest paper on how Beta-2-glycoprotein I (B2GPI) moves.

We have used the laboratory's high performance computing suite to take models of B2GPI and modify them to match versions we see in blood. Then we have taken this and measured how it would move in the blood, to see if there are differences in how different versions of B2GPI behave.

The link for the whole paper is here: https://pubmed.ncbi.nlm.nih.gov/42162085/

But long story short, all the common modifications have an effect on how B2GPI moves, and that might mean that the antibodies seen in APS (against B2GPI) might be generated due to changes in the circulating B2GPI, meaning there are circulating targets to investigate!

We are hoping to put out a video about this paper to run through the main findings so keep an eye out!

APS Patient Day

It was an enormous pleasure to attend and speak at the Hughes APS Trust patient day. I spoke about antibodies, and how they come about. It was fantastic to speak to so many people so keen to contribute to research. The patients were so passionate and asked really keen questions, really probing some of the clincal staff!

It was a unique experience to present to my own parents too, and one I wont quickly forget!

Many thanks to the Hughes APS trust for the invitation, and I hope to be at the next one too!

Announcing...Zoe!

We have a new PhD Student in the lab! Welcome Zoe - she comes to work with us from the award winning Hemer Lab (Check them out here: https://profiles.ucl.ac.uk/87008-katie-a-hemer).

Her project will be based around ancient immunology, using proteomic approaches to catalogue the ancient immune system with the aim of finding ancient autoimmunity. Oh you thought autoimmunity was a new thing? Old as bones.

We are all looking forward to what you find Zoe!